Sign Of A Victory triumphed at Ascot on 1 November
Garde La Victoire has been left with top weight following the five-day confirmations for The Ladbroke at Ascot on Saturday.
The Philip Hobbs-trained Greatwood Hurdle winner has been left at the head of the pile following the defection of Zamdy Man, who ran at Cheltenham at the weekend.
Hobbs said: "I'm glad it's been dry recently as the better the ground the better his chance.
"We thought about running him in the Relkeel at Cheltenham but he'd have been giving weight to horses rated higher than him so it just made no sense."
Hobbs also has Exeter regular Hello George in the valuable handicap hurdle, for which there are 22 horses remaining.
Sign Of A Victory, trained by Nicky Henderson, has been earmarked for this race since winning the William Hill Handicap Hurdle at Ascot over six weeks ago and is a leading ante-post fancy.
The Seven Barrows handler has a second possible in Cool Macavity but he has taken out his other entries, including recent Sandown scorer Snake Eyes, while John Ferguson is double-handed with Ruacana and Pine Creek.
Activial is also a major player for the Harry Fry operation.
There is a strong Irish representation, with Willie Mullins leaving in Greatwood third Clondaw Warrior.
Gordon Elliott could saddle Bayan and Shadow Catcher, with Tony Martin's Pyromaniac and Sea Beat from Arthur Moore's stable the other Irish acceptors.
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